One day in June 2011, there was a 21-year-old boy in the waiting room of the urology clinic of Zhongshan Hospital, who was always fidgeting and looking at the waiting signs, running to the opposite toilet every ten minutes or less, and had gone to the toilet four times in just half an hour. After entering the consultation room, the doctor asked to know that the young man surnamed Li, more than 7 years ago began to appear contact “K” powder, from more than a year ago began to appear frequent urination, urinary urgency, lower abdominal and perineal pain, the number of times per day urination, each urine volume decreased, so he began a long road to seek medical treatment, has gone to a number of hospitals for treatment, some said he Some said he had a urinary tract infection, others said he had urinary tract tuberculosis, and he took a lot of medicine, but the urinary discomfort kept getting worse, and now he urinates almost 40 or 50 times a day. The urologist asked him about his medical history and treatment and then suggested that he be hospitalized for detailed examination to determine the next treatment plan after a clear diagnosis. After his admission, the doctor did a comprehensive examination and made it clear that he was suffering from ketamine-associated cystitis. After a rigorous and careful preparation the doctor gave Xiao Li a multi-point injection of transcystoscopic forced urine toxin. After the catheter was removed the day after the surgery, Xiao Li still felt urgency and perineal distention. When he inquired, the doctor told him that the effect of the medicine would only show up 3 to 7 days after the surgery, and to continue to observe while taking Chinese herbal medication. That night, Xiao Li found that he urinated less often and only got up 2 times a night to go to the toilet. After 2 more days, Xiao Li happily told the doctor that he now urinated only once an hour or so, and the volume of urine each time was more than before. On the sixth day after the operation, Li was discharged from the hospital with his family in tow, full of joy. The company’s main business is to provide a wide range of products and services to the public. Overdose or long-term smoking can cause fatal damage to the heart, lungs and nerves, and the damage to the central nervous system is even more powerful than methamphetamine. In recent years, it has been found that long-term and frequent application of ketamine can also cause damage to the urinary system, which has been reported in the literature both at home and abroad. Some users have to go to the toilet in 10 minutes and can only hold 30-50ml of urine each time, and even develop hydronephrosis and kidney function damage. Due to the lack of effective medication, many hospitals have reported surgical treatment for these patients, removing the contracted bladder, replacing the bladder with an intestine or wearing a urine bag for life to reduce the damage to the kidneys. However, this surgery is destructive, not only is it dangerous and expensive, but there are many post-operative complications, and it is generally used for the treatment of intermediate and advanced bladder tumors, which is a last resort and should not be applied as a last resort. Botulinum toxin is a presynaptic inhibitor at the neuromuscular junction that, when injected into the muscle in small doses, causes selective and reversible muscle paralysis that lasts for several months. Different medical disciplines have found Botox to be useful in the treatment of muscle spasticity disorders. In the field of urology, Botulinum toxin A has been used to treat lower urinary tract dysfunction such as neurogenic detrusor overactivity, detrusor sphincter synergism, motor or sensory urgency. Ketamine-associated cystitis can also be treated with good results using transcystoscopic multipoint injections of forceps muscle toxin with pelvic floor muscle electrical nerve stimulation therapy and herbal conditioning due to the urodynamic manifestation of uninhibited contraction of the forceps muscle of the bladder. Any effective treatment method has a premise, that is, you must stop taking ketamine, otherwise, even if there is a good effect will be a short-term relapse. At present, China has included “ketamine” in the same drug category as methamphetamine, morphine, and dulcolax, and is cracking down on the sale and consumption of “ketamine”. I hope you are fully aware of the harm caused by “K-powder” abuse to the human body and society, and do not believe that “K-powder” is not addictive and try it.