Thigh muscle pain may be related to muscle strain, lumbar disc herniation, pyriformis syndrome, etc., and need to be treated conservatively or surgically, there is no fastest way to solve the problem. 1. For thigh pain caused by muscle strain, stop the activity immediately and pay attention to rest; take oral ibuprofen and other non-steroidal anti-inflammatory drugs as prescribed by the doctor for pain relief; if the muscle is torn or broken, surgical repair is needed. 2. For thigh pain caused by lumbar disc herniation, oral ibuprofen and other non-steroidal anti-inflammatory drugs, methylcobalamin and other nutritive nerve drugs can be taken as prescribed by the doctor; if the effect of conservative treatment is not obvious, surgery can be performed to relieve the compression. 3. For thigh pain caused by pyriformis syndrome, it is necessary to comply with medical advice oral celecoxib and other non-steroidal anti-inflammatory drugs, local injection of glucocorticosteroids such as prednisone, or lidocaine and other local anesthetic; conservative treatment is ineffective, can be considered to carry out the pyriformis tendon amputation and sciatic nerve decompression surgery. It is recommended that people with thigh tendon pain go to a regular hospital in time to clarify the cause of the disease and standardize the treatment under the guidance of the doctor, so as not to delay the condition. Drugs should be used in accordance with medical advice.