Chemotherapy is one of the main treatments for advanced lung cancer. Chemotherapy is used in advanced lung cancer as long as the physical condition can tolerate chemotherapy. If the health condition is not good, i.e. KPS score below 70 is not suitable for chemotherapy or intense chemotherapy, then single agent chemotherapy or beat chemotherapy can be used. If there is genetic mutation, targeted drugs can be used for treatment, because the side effects of targeted drugs are mild, they can be taken orally and can be treated at home. Therefore, advanced lung cancer is not necessarily unsuitable for chemotherapy, but mainly depends on the patient’s physical condition, pathological type and the patient’s willingness for treatment to be considered comprehensively. Chemotherapy can be implemented in advanced stage of lung cancer, and it can prolong patients’ progression-free survival time and improve their quality of life.