Treatment options for systemic folliculitis require targeted medication based on the different presenting features of the rash. If it is severe, with cysts and large nodules, it can be treated with dye laser or photodynamic therapy. If only follicular papules and small acne-like rashes are present, oral and topical medications can be used. Oral medication can choose isotretinoin capsules, viamin capsules, minocycline hydrochloride capsules. However, because of the teratogenic effect of viaminate capsule or isotretinoin capsule, it is necessary to explain the condition of the patient carefully before taking them, and the patient can only use them if he agrees. Topical drugs can choose clindamycin phosphate gel, fusidic acid cream, compound polymyxin B ointment, ofloxacin gel, or Fuqing gel.