Parkinson’s disease levodopa can not be taken with vitamin B6 reasons: levodopa is the main drug for the treatment of Parkinson’s disease, has the effect of anti-tremor paralysis, when combined with vitamin B6, it will greatly reduce the effect of levodopa, so as to fail to achieve the therapeutic purpose. Levodopa has good efficacy in tremor, tonus, and bradykinesia, and should be used with caution in those with active peptic ulcers and those with closed-angle glaucoma. Vitamin B6 can promote nucleic acid synthesis, reduce nocturnal muscle spasm, etc., allergic to this product should be used with caution, the dose should be strictly in accordance with medical advice. When combined with levodopa, it will enhance the activity of dopa decarboxylase, resulting in the change of levodopa into dopamine, and due to the existence of the blood-brain barrier, dopamine can not enter the brain, resulting in a significant reduction in the therapeutic effect. The combination of the above two drugs is unfavorable to the treatment, and it is recommended that patients use the drugs under the guidance of a doctor, not blindly self-medication.