High palatal arch is the main manifestation of Marfan’s syndrome. The main danger of this disease is cardiovascular lesions, especially the combined aortic aneurysm, which should be detected early and treated early. The diagnosis can be made based on the three main signs of clinical manifestations: skeletal, ocular and cardiovascular changes and family history. Clinically, there are two types: those with all three main signs are called complete; those with only two are called incomplete. The primary defect of the high palatal arch is unknown; it has been suggested that the lateral association between elastin and collagen tissue peptide chains is impaired, i.e., a lysyl oxidase defect. It is also associated with acidic mucopolysaccharide deposition, increased salivary acid, hyaluronic acid accumulation, and poor or excessive destruction of chondroitin sulfate formation. In addition, high palatal arches are commonly associated with Marfan’s syndrome, which was officially named Marfan’s syndrome by Weve in 1931 after a large collection of cases, and is considered to be a dominantly inherited disease. In the past, abnormal changes in connective tissue extracellular matrix molecules, such as collagen, elastin and hyaluronic acid, have been considered as the cause of the disease. 1, premarital examination: including detailed inquiries about the health status of both men and women and their family members past medical history and treatment, especially the presence of congenital malformations, genetic history and history of consanguineous marriage. Family lineage survey, blood type examination chromosome examination or genetic diagnosis should be conducted to detect carriers. 2, genetic counseling: one of the couple or their relatives have a certain genetic disease or congenital malformation, ask the occurrence of similar diseases in the offspring; if a certain genetic disease or congenital malformation has been made, ask about the offspring and how to prevent the birth of affected children when having children again. If you have suffered from a disease, taken a drug or been exposed to toxic substances or radiation during pregnancy, ask about the possible condition of the fetus.