High-grade squamous intraepithelial lesions are a type of precancerous lesion, also known as intraepithelial neoplasia, and are traditionally classified into three levels, called mild atypical hyperplasia, moderate atypical hyperplasia, and severe atypical hyperplasia. High-grade squamous intraepithelial lesions mainly include moderate atypical hyperplasia, severe atypical hyperplasia, and carcinoma in situ, which is generally considered to be a so-called clinical carcinoma only when it reaches the level of invasive carcinoma. For high-grade squamous intraepithelial neoplasia, it is appropriate to choose Lipo knife surgery to remove it, and the prognosis of high-grade intraepithelial neoplasia is relatively good. The prognosis of high-grade intraepithelial neoplasia is relatively good. Regular postoperative review is sufficient, and it will not cause much impact on the body.