The treatment of neonatal intracranial infection, including antibiotic treatment, symptomatic management, supportive therapy and glucocorticoids. 1. Antibiotic treatment: emphasize on early medication, reasonable medication, combination of medication, and full course of treatment. Due to the existence of the blood-brain barrier, attention should be paid to the selection of antibiotics that pass the blood barrier better, and the dose generally needs to be doubled. Such as ceftriaxone sodium. 2. Symptomatic treatment: stop the alarm using sodium phenobarbital, intracranial pressure increased with mannitol to reduce intracranial pressure. 3. Supportive therapy: ensure water and electrolyte balance, ensure energy supply. 4. Glucocorticoids: have the effect of reducing inflammatory exudation and reducing cerebral edema, and can be used as appropriate in newborns. When the neonate found intracranial infection, should go to the hospital in time, under the guidance of the doctor’s treatment. All of the above drugs should be used under the guidance of a doctor.