Deep vein thrombosis (DVT) refers to the abnormal clotting of blood in the deep vein system, which is usually found in the lower extremities, and is a typical disease that can affect all ages, races and classes. High blood viscosity, slow blood flow and damage to the vascular wall are the three main causes of this disease, which mostly occurs in people who are bedridden after various surgeries, chronic diseases and people with limited limb movement due to various reasons. The most common clinical manifestation of this disease is the sudden swelling of one limb and local pain. According to the site of embolized vessels, it can be divided into: ① peripheral type: below the lower segment of superficial femoral vein; ② central type: iliofemoral vein thrombosis; ③ mixed type: regardless of peripheral or central type, it can involve the whole limb by proliferation or retrograde expansion, which is called mixed type and is most common clinically. Severe patients, due to heavy swelling of the limb, affect the blood supply of lower limb arteries, called femoral cyanosis, have high mortality and disability rate, and need emergency surgery. if DVT patients are not effectively treated in the early acute stage, venous insufficiency is often left after thrombosis mechanization, called post-thrombotic syndrome, which seriously affects the quality of life of patients. The immediate goals of acute lower extremity DVT treatment are to control symptoms, reduce thrombotic load, and prevent the occurrence of femoral cyanosis; to prevent pulmonary embolism caused by spreading and dislodging of thrombus; and the long-term goals are to promote venous recanalization and preserve as many valves as possible; to reduce the occurrence of post-thrombotic syndrome; and to prevent the recurrence of thrombus. Anticoagulation therapy accelerates endogenous fibrinolysis and prevents fresh thrombosis and recurrence. Therefore, anticoagulation therapy is unquestionably indicated for both immediate and long-term goals. However, in patients with contraindications to anticoagulation that preclude anticoagulation, and in patients at high risk for thrombus dislodgement, the use of anticoagulation is not effective in preventing thrombus dislodgement and pulmonary embolism. In order to prevent pulmonary embolism, temporary and permanent filter placement in the inferior vena cava has been used in recent years to prevent pulmonary embolism and significantly reduce the incidence of pulmonary embolism. Many clinical studies have shown that in the acute phase of DVT, direct thrombolysis by placing a thrombolytic catheter into the thrombus can significantly reduce the incidence of post-thrombotic syndrome and improve the quality of life of patients in nearly 70% of cases of early recanalization of the affected limb. It is one of the most promising modalities for the treatment of acute DVT.