Xiao Lin, a teacher in a school, has not been in a good state of mind for the past two months, feeling rather tired, unable to do anything, and her appetite is also very poor. Recently, colleagues also found that Xiao Lin’s skin was yellow, and even the sclera of her eyes was yellow, so they rushed to remind her to go to the hospital for examination. When she came to the community hospital, the doctor asked about her symptoms and suspected that she had hepatitis and sent her to Xiamen Second Hospital for examination and treatment. After liver function, blood routine, urine routine, the doctor found that Xiaolin not only had elevated jaundice indicators, but also had a significant drop in hemoglobin, which was only half of normal. So, Xiaolin was admitted to the hematology department for inpatient treatment. After another diagnosis, the doctor found that Xiao Lin had autoimmune hemolytic anemia, and after controlling Xiao Lin’s own “abnormal immunity” with medication, Xiao Lin’s condition improved significantly and the jaundice symptoms disappeared, and his eyes returned to their original state. Jaundice is a clinical symptom, not a separate disease Why does jaundice occur in hemolysis? Jaundice is due to a disorder of bile pigment metabolism. After hemolysis, the bilirubin content in the plasma increases beyond a certain level, causing yellow coloring of the plasma, skin, mucous membranes and sclera, i.e. jaundice. Jaundice is a clinical symptom, not an independent disease. Therefore, yellowing of the skin does not necessarily mean that you have hepatitis. As long as the concentration of indirect bilirubin or direct bilirubin in the blood is increased, jaundice can occur, and hepatitis is only one of the causes of hepatic jaundice. When you encounter a patient with jaundice, you should make a comprehensive judgment based on the specific situation and combine the results of various tests to find out the cause of jaundice, and never arbitrarily assume hepatitis at the first sight of jaundice. Hemolysis is very dangerous Autoimmune hemolytic anemia is a representative disease of hemolytic jaundice. It is caused by abnormal hyperfunction of B-lymphocytes, which produce anti-erythrocyte autoantibodies, leading to accelerated destruction of red blood cells, resulting in jaundice and anemia. According to its etiology, it is divided into two categories: unknown (primary) and secondary. As diagnostic techniques become more sophisticated, the proportion of secondary cases is gradually increasing, often secondary to malignant neoplasms of the hematopoietic system (e.g., leukemia, lymphoma, myeloma, and macroglobulinemia of unknown origin), rheumatic diseases (e.g., systemic lupus erythematosus, scleroderma, rheumatoid arthritis), immune diseases (e.g., hypogammaglobulinemia, abnormal globulinemia, immunodeficiency syndrome), infectious diseases, especially viral infections in children, chronic inflammatory conditions (e.g. ulcerative colitis) and benign tumors (e.g. ovarian dermatomycosis). Hemolytic jaundice is sometimes accompanied by chills, high fever, back pain, vomiting and diarrhea, and even shock and neurological manifestations such as headache, irritability and even coma. If symptoms are severe and not well controlled by medication, treatment such as blood transfusion, splenectomy, or plasma exchange may also be required. We would like to remind everyone that once you find out that you have hemolytic jaundice, it is best to treat it promptly. Hemolysis is very dangerous and can be life-threatening if not treated in time.