Very severe diarrhea is associated with factors such as rotavirus, cholera, and bacillary dysentery. Most of the diarrhea is caused by bacterial and viral infections in the intestinal system, which will not only cause more frequent diarrhea, but even mucus, pus and blood stools in some people. Rotavirus is mainly found in the body of infants and young children, especially in the fall and winter seasons are more prone to hair, in the attack of the patient’s diarrhea is more serious, is mainly watery stool, egg-shaped stool, the need to timely use of montelukast to stop diarrhea treatment. Cholera is an intestinal disease caused by Vibrio cholerae infection, which is a class A infectious disease, not only is the onset of the disease more acute, but also lead to dehydration, muscle spasms, and the function of the kidneys will also be affected, cholera is not treated in time, and even threaten the patient’s life. Bacterial dysentery is a disease caused by dysentery bacillus infection, dysentery bacillus will cause damage to the intestinal mucosa, resulting in intestinal mucosal necrosis, detachment, and at the same time on the intestinal absorption function, so it will cause severe diarrhea.