It is not normal for platelets to drop after vaccination, and it is important to seek medical attention to rule out other diseases. Generally speaking, vaccination does not cause platelet drop. After entering the human body, vaccines mainly stimulate the immune system to produce antibodies to prevent diseases. Thrombocytopenia is a hematologic disorder, and vaccines generally do not have a similar direct effect. Therefore, we need to consider the possibility of other diseases, such as systemic lupus erythematosus of the immune system, which can cause a significant decrease in platelets, is a typical symptom of such diseases, and we need to consult a doctor in time for systematic examination. The specific cause of the disease needs to be clarified after medical examination, and at the same time follow the doctor’s instructions to actively treat.