Children who still have fever after using antipyretic suppositories can be seen to use insufficient dosage, observation time is not enough or condition-related factors, intervention needs to be decided according to the cause, such as adjusting the dose of medication, adjusting the observation time, physical hypothermia, medication and so on. 1. Insufficient dosage: If a child still has a fever after using antipyretic suppositories (e.g., ibuprofen suppositories or acetaminophen suppositories), it is necessary to assess whether the dosage of the medication used is appropriate, which is often based on the child’s body weight, and if the dosage is insufficient the above phenomenon may occur, and the treatment needs to be correctly used under the guidance of the physician to use the antipyretic suppositories. 2. Insufficient observation time: it is usually believed that after the correct use of antipyretic suppositories, the body temperature can be in 30 minutes ~ 1 hour or so body temperature gradually decline, some of the children in the acute phase of the disease in the use of drugs in 2 ~ 3 hours before the decline in the observation time is not enough can also appear the above phenomenon, we need to continue to monitor the body temperature, observation of the state of the body temperature, as appropriate, the use of lukewarm water wiping and other means of physical hypothermia. 3. Disease-related factors: such as intracranial infections, serious respiratory infections and other diseases, can appear reasonable use of antipyretic suppositories ineffective, such children need to be reassessed by specialists to adjust the treatment program, such as refractory Mycoplasma pneumoniae pneumonia, need to be guided by a physician to use methylprednisolone sodium succinate anti-infective treatment if necessary. If the fever persists despite the use of antipyretic suppositories, it is recommended that the child go to the hospital as soon as possible for evaluation and treatment by a specialist.