Loofah seeds do not cure knee pain. Loofah seeds are mainly used for the treatment of lung heat cough, phlegm, and so on. Loofah seeds for the cucurbit plant seeds of loofah, bitter taste, nature, with heat, phlegm, laxative, insect efficacy, clinically used in the treatment of constipation, intestinal wind, hemorrhoidal impotence, ascariasis, and other diseases of the treatment. There is no clear effect and role in the treatment as well as improvement of knee pain. Pregnant women need to use with caution. Although the seeds can be used to treat a variety of diseases, but must be used under the basis of traditional Chinese medicine diagnosis. Moreover, there are some differences in the way of administering the drug for different diseases, so it is important to strictly follow the doctor’s instructions and use the right way of applying the seed of lucerne in order to make the drug give full play to its due efficacy.