At present, insulin pump treatment in the population of diabetic patients more and more, the related adverse reactions also need to pay attention to the following points: 1, the insulin pump injection site to choose a good, if you choose too close to the navel, often there will be subcutaneous bleeding, hard nodules, serious cases can appear skin infection. So for patients treated with insulin pump, the location of the insulin pump should generally be chosen from the belly button 5cm away from the abdomen where the fat is thicker. In addition, we should pay attention to local cleanliness, whether there is local redness, swelling, itching and subcutaneous bleeding, and if the insulin pump line is not replaced for a long time, there is also a risk of subcutaneous hard nodules. 2, insulin pump treatment process will have a blockage of the tube, and insulin pump pipeline replacement is not timely, insulin pump treatment time should not exceed 5-7 days, monitoring blood glucose if significantly higher, to timely replace the insulin pump pipeline, in order to prevent the blockage of the insulin pump pipeline caused by increased blood glucose.