Atorvastatin and Rosuvastatin both have good lipid-lowering effect, can’t compare which one is better, need to be chosen by the doctor according to the patient’s condition. Atorvastatin is mainly used for hypercholesterolemia and coronary heart disease, common adverse reactions include myalgia, diarrhea, nausea, transaminase elevation, etc. It is contraindicated in active liver disease, drug allergy, pregnancy and lactating women. Rosuvastatin is mainly used for hypercholesterolemia, mixed dyslipidemia, common adverse reactions include dizziness, headache, constipation, abdominal pain, myalgia, etc. It is contraindicated in active liver disease, drug allergy, pregnancy, lactation, and severe renal impairment, as well as the use of cyclosporine patients. The difference between the two is that atorvastatin is metabolized by the liver, and Rosuvastatin is metabolized by the liver and kidney dual-channel metabolism, so patients who need to use statins but have liver damage can choose Rosuvastatin, and patients with kidney damage can choose atorvastatin. Therefore, it is impossible to directly compare the two drugs which is better, need to combine with the patient’s renal function, combined use of drugs and other circumstances of comprehensive consideration, under the guidance of the doctor to use drugs.