Deficiencies in vitamins such as folic acid, pyridoxine (B6) or cobalamin (B12) all increase homocysteine levels as a result of biochemical reactions. Supplementation with pyridoxine, folic acid, cobalamin or trimethylglycine will reduce the concentration of homocysteine in the blood. Homocysteine is moderated by high concentrations of polyphenol antioxidants, which are thought to have certain health benefits for the cardiovascular system and immune system. Polyphenol antioxidants can modulate the formation of reactive oxygen species, an important compound in cardiovascular disease. The auto-oxidation of homocysteine to reactive oxygen species can lead to biological damage. People with high homocysteine are prone to thrombosis and cardiovascular disease, but this is usually not a problem and can be normalized through diet and medication. Lower HDL cholesterol is also a potential factor for cardiovascular disease. Generally, the higher the HDL cholesterol, the less likely you are to get cardiovascular disease, and high triglycerides are also a detrimental factor for cardiovascular disease. These abnormalities are very common in clinical practice, especially in obese patients, and may be caused by long-term consumption of high-fat diet, lack of exercise, and too little intake of vegetables and fruits. Usually there is no major problem, and can be restored to normal through diet control and exercise. Therefore, it is recommended to eat more vegetables and fruits, control the intake of high-fat food, low-salt diet, quit smoking and limit alcohol, and exercise more, no special treatment is needed. Folic acid is widely found in fresh dark green vegetables, and in liver, meat, milk, yeast, fish, beans, egg yolk, nuts, cheese, etc.