Pediatric nephrotic syndrome will not be cured as children grow older, and requires standardized treatment to be cured. Nephrotic syndrome is a group of syndromes characterized by massive proteinuria, hypoproteinemia, edema, and hyperlipidemia. It is very unlikely that this disease will recover on its own as the child grows older, so it needs to be treated actively. Currently, the first-line treatment for nephrotic syndrome is oral hormone therapy, which usually takes about 6-9 months. If there is any relapse in the course of treatment, it is necessary to follow the doctor’s instructions to add some other drugs according to the condition to cooperate with the treatment, such as immunosuppressants, biologics, and children can usually recover through regular use of medication. Therefore, children with pediatric nephrotic syndrome should not wait passively to avoid life-threatening complications such as acute kidney injury, thrombosis and embolism, as well as serious infections, and must be actively treated.