Tearlessness occurs when the lacrimal glands are not developed congenitally, or due to an acquired autoimmune system disorder that disrupts lacrimal secretion, resulting in the desire to cry without tears. Tearlessness, an eye disease that cannot be cured, patients can only rely on medicated ointments to improve symptoms or use special moisturizing glasses to avoid water evaporation. Tear spot closure treatment can be used to reduce tear loss. Drops of artificial tears can also improve symptoms. Preventive measures include avoiding marriage between close relatives, pushing preventive measures include avoiding marriage between close relatives, promoting genetic counseling, carrier genetic testing and prenatal diagnosis and selective abortion to prevent the birth of affected children. Genetic counseling, carrier genetic testing and prenatal diagnosis and selective abortion are pursued to prevent the birth of affected children.