Whether jaundice is metastasis or not in the late stage of pancreatic cancer is mainly determined by the location of the primary lesion. If the primary lesion is far away from the bile duct, jaundice is very likely to belong to metastasis; if the primary lesion is located around the bile duct, jaundice is not necessarily caused by metastasis. 1. The primary lesion is far away from the bile duct: when pancreatic cancer enters the advanced stage, if the lesion occurs in the tail part of the pancreatic body, the lesion itself is far away from the biliary system, most of the lesion does not cause jaundice, and the corresponding condition may be caused by the tumor metastasis to the periphery of the common bile duct, which results in the obstruction caused by the infringement of the bile duct. 2. The primary lesion is located around the bile duct: pancreatic cancer itself is located in the head of the pancreas, with the progress of the lesion, the tumor will directly invade the biliary system, causing obstruction and jaundice, and the jaundice in this case is not necessarily caused by metastasis. If pancreatic cancer is suspected or diagnosed, it is recommended to go to regular hospitals to evaluate the condition and follow the doctor’s instructions to avoid delaying the condition.