Dry syndrome (SS) is a chronic inflammatory autoimmune disease mainly involving exocrine glands, also known as autoimmune exocrine gland epithelial cellulitis or autoimmune exocrinopathy. In addition to dry mouth and eyes due to decreased function of salivary and lacrimal glands, there are also symptoms of multisystemic damage due to involvement of other exocrine glands and other organs outside the glands. The disease is characterized by a variety of autoantibodies and hyperimmunoglobulinemia in the serum. The disease is divided into two categories: primary and secondary. Treatment There is no cure for this disease. The main measures are to improve the symptoms, control and delay the progress of tissue and organ damage caused by immune response and secondary infection. 1.Improve the symptoms (1) Reduce the symptoms of dry mouth, keep the mouth clean, rinse the mouth regularly, reduce the possibility of dental caries and oral secondary infection. (2) Dry keratitis and conjunctivitis can be given artificial tear drops to reduce dry eye symptoms and prevent corneal damage. (3) For muscle and joint pain, non-steroidal anti-inflammatory drugs and hydroxychloroquine can be used. (2) Systemic damage should be treated according to the severity of the damaged organs. Adrenocorticotropic hormone should be given in the same dose as other connective tissue diseases for combined neurological diseases, glomerulonephritis, interstitial lung lesions, liver damage, low blood cells, especially low platelets, and myositis. Immunosuppressive agents such as cyclophosphamide and azathioprine may be used in combination with other drugs for rapidly progressing disease. Aggressive and timely combination chemotherapy is recommended for those who present with malignant lymphoma.