Perianal abscesses treated with cephalosporin antibiotics are usually not completely eliminated. Cephalosporin is a general term for cephalosporin antibacterial drugs, a class of antibiotics obtained by semi-synthetic modification of natural cephalosporin C as raw material. Antibiotics in the treatment of perianal abscess can only play a bacteriostatic sterilization anti-infection role, and can not completely cure perianal abscess, so that the abscess goes down. Perianal abscess is an acute purulent infection of the soft tissues around the anal canal and rectum or the peripheral space. Perianal abscess with cephalosporin antibiotic treatment, can play the role of antibacterial sterilization, but, because the infection of the abscess has formed pus cavity pus, with antibiotics has not been able to make the formation of pus pus infection control, so purely with the cephalosporin antibiotics can not eliminate the formation of perianal abscess infection. Once the patient’s perianal abscess is formed, the abscess should be incised and drained as soon as possible, and at the same time given anti-infective, such as cefixime, amoxicillin, ciprofloxacin and other sensitive antibiotics to avoid further spread of infection. Superficial abscesses, such as perianal subcutaneous abscesses, can be done under local anesthesia, while deeper abscesses need to be done under lumbar anesthesia or even general anesthesia. It is recommended that when suffering from perianal abscess, should be timely under the guidance of the doctor for standardized treatment, daily life should pay attention to the cleanliness of the skin around the anus, avoid spicy and irritating food.