Creatinine elevation caused by short-term administration of tacrolimus can usually be recovered by stopping the drug and replacing it with another one; if it leads to serious impairment of renal function after long-term administration, it usually cannot be fully recovered, so the actual condition of the patient should prevail. Therefore, the use of this drug need to strictly monitor the renal function, in order to avoid causing serious adverse reactions. Tacrolimus belongs to the calcium-modulated neural phosphatase inhibitor, with immunosuppressive effect, can be used to prevent the rejection of liver and kidney transplantation, treatment of liver or kidney transplantation after the application of other immune-suppressing drugs can not be controlled by the rejection of grafts. Tacrolimus may cause adverse reactions such as elevated blood creatinine and urea nitrogen, nephrotoxicity, hyperkalemia and hypertension. If patients take tacrolimus for a short period of time and the creatinine rises, they can usually recover by stopping taking it and replacing it with another drug; if long-term use of tacrolimus leads to serious impairment of renal function, it is usually impossible to recover completely, and if it progresses to renal failure, it is necessary to undergo hemodialysis and other treatments. In addition, if the blood creatinine is elevated due to the rejection reaction after kidney transplantation, it may not be possible to recover the blood creatinine by changing drugs, and it is recommended to take the actual situation of the patient as the basis. It is contraindicated in people who are allergic to tacrolimus or other macrolides and those who are allergic to any excipients of this product. The use of this drug must be under the supervision of a physician.