Possible causes of pimples on the cheeks include rosacea, acne and other diseases. 1. Rosacea: Acne in the middle of the face, especially in the cheeks, may be due to rosacea, rosacea is a persistent erythema and capillary dilatation of the main chronic inflammatory skin disease, especially the papular pustular rosacea. It can show more obvious pinpoint to mung bean size pimples and pustules in the middle of the face, thus causing the manifestation of acne on the cheeks, and the acne symptoms and erythema symptoms may be aggravated when subjected to external stimulating factors. 2. Acne: The sebaceous glands in the cheek area are more distributed, such as the presence of Propionibacterium acnes infection, sebum secretion is blocked, inflammation may cause acne, which leads to the phenomenon of pimples on the cheeks, so pimples on the cheeks may also be caused by acne. Acne is what we call pimples in our daily lives, and can manifest itself in a variety of lesions such as pimples, inflammatory papules, pustules, nodules, cysts, and scarring. It should be noted that the appearance of acne on both cheeks should be promptly consulted, and the above treatment should be carried out under the guidance of a physician to avoid the occurrence of adverse reactions.