If men experience painful urination, then further examination is recommended to clarify the cause of the painful urination before symptomatic treatment. The possible causes and treatments are as follows: 1. Acute or chronic urethritis, when pain in the urethra during urination can occur, routine urine tests and urine culture tests can be performed. If the presence of an infection is confirmed, it is recommended that sensitive antibiotics be selected for treatment based on the test results. One capsule of levofloxacin hydrochloride can also be applied empirically, three times a day, orally for three consecutive days, and observe whether the painful urination improves. 2. When suffering from urethral stones, pain during urination can also occur and can even be accompanied by bleeding from the urethra or hematuria, etc. Ultrasound or X-ray examination of the urinary tract is recommended to rule out the presence of stones. If there are stones, it is recommended that comprehensive treatment such as lithotripsy under urethroscopy to remove stones; 3. Male prostatitis and prostate enlargement can cause painful urination. Young men often suffer from prostatitis, except for painful urination may be accompanied by discomfort in the perineal area, or frequent urination, urinary urgency, etc. It is recommended to perform a prostate fluid examination, if there is an infection, prostatitis, etc. It is recommended to take one oral cefixime capsule twice a day for one week. If older men, routine urinary ultrasound examination is performed to rule out the presence of prostatic hyperplasia. If prostatic hyperplasia is present, it is recommended to take one capsule of tamsulosin hydrochloride extended-release capsule orally once a day for one month.