Congenital syphilis can be cured through timely, adequate, regular and regular treatment, life expectancy is no different from normal people. Early fetal syphilis can choose benzylpenicillin intramuscular injection if the cerebrospinal fluid is normal; if the cerebrospinal fluid is abnormal, aqueous penicillin can be used for intravenous injection or procaine penicillin G intramuscular injection. Erythromycin can be used in allergic patients. Late congenital syphilis can choose procaine penicillin G intramuscular injection, the amount of treatment should be careful not to exceed the amount of adults in the same period. Specific treatment amount and time can be carried out under the guidance of the doctor. After the expulsion of syphilis treatment, it is necessary to pay attention to the regular review of serum. Clinical symptoms can disappear after regular treatment, and the syphilis seroprevalence has changed from positive to negative within 2 years of follow-up, or the serology is fixed, which is the clinical cure.