Coughing up sputum with blood in the morning and then coughing it up again, the first thing you should do is to identify the cause of the illness and treat it accordingly. Common possible causes are nasopharyngeal diseases, oral diseases, lung diseases, and other diseases such as blood system diseases. 1. Nasopharyngeal diseases: common in acute pharyngolaryngitis, the mucous membrane of the pharynx may be due to inflammation and local bleeding, coughing up sputum in the morning along with sputum, but also due to bleeding in the nasal cavity, and coughing up sputum at night along with sputum in the pharynx due to postnasal drip during sleep. Most of them can be treated with localized nebulized inhalation, taking heat and toxin removing drugs such as Pu Dilan Anti-inflammatory Oral Liquid. 2. Oral diseases: common in periodontitis, pulpitis and other local bleeding, may flow back into the throat during sleep at night, coughing up sputum with blood in the morning, often available drugs, including compound borax liquid (tablets), furacilin liquid. 3. Lung diseases: common in tuberculosis, bronchiectasis, lung tumors and so on. Tuberculosis can be used ethambutol, rifampicin and other drugs, bronchiectasis combined with bacterial infection commonly used anti-infective drugs such as cephalosporin, penicillin and so on. Lung tumors need to be clearly staged to give targeted treatment. 4. Other: such as blood system diseases – thrombocytopenic purpura, leukemia, etc. may lead to sputum with blood in the morning, need to give appropriate treatment for the condition. Coughing up sputum with blood in the morning and then coughing it up again may also have other causes, such as pulmonary embolism, pulmonary heart disease, etc., so it is recommended to go to the hospital in a timely manner to find out the cause of regular treatment. All of the above medications should be used under the guidance of a doctor, avoid self-medication.