The presence of acne on both sides of the cheeks is mostly caused by acne, and the common clinical treatments for acne include general treatment and medication. 1. Acne is a chronic inflammatory disease that occurs in the sebaceous gland units of the hair follicles and is most common in adolescents. The general treatment commonly used in clinical practice includes choosing appropriate cleansing products, limiting the intake of high-sugar foods and milk, and ensuring that the bowels are unobstructed, etc. The general treatment of acne includes the use of a variety of medications. 2. Medication, the commonly used medications for acne include first-generation isotretinoin, benzoyl peroxide, and antibiotics such as doxycycline, etc. If acne occurs on both sides of the cheeks, it can be treated as a chronic inflammation. If acne appears on both sides of the cheeks, it is recommended to go to the dermatology department of the hospital as soon as possible, under the guidance of the doctor to standardize the treatment, and follow the doctor’s instructions to standardize the treatment.