The treatment methods for locally advanced lung adenocarcinoma include radiotherapy, chemotherapy and surgery, which need to be chosen according to patients’ specific conditions. Most of locally advanced lung adenocarcinomas are in stage III, that is to say, the tumors are large in size and accompanied by lymph node metastasis, but without metastasis to distal organs. At this time, it is more difficult to perform surgery, and most of the treatments such as radiotherapy and chemotherapy are mainly used to stabilize the patient’s condition so as to prevent it from deteriorating continuously. If the tumor shrinks after a period of treatment and the staging is downgraded, surgical resection can be considered if the indications for surgery are met, followed by a period of radiotherapy, chemotherapy or targeted therapy.