The saturation and concentration of uric acid in the body at 37°C is about 420 μmol/L (7 mg/dl), and above this concentration is hyperuricemia. The main clinical drugs to lower uric acid are: 1. Uric acid excreting drugs: the mechanism of these drugs is to inhibit the reabsorption of uric acid salts in the proximal renal tubules, thus increasing the excretion of uric acid and lowering the level of uric acid. These drugs are suitable for people with good kidney function, and they should drink more water and take sodium bicarbonate 3~6g/d. Commonly used drugs are: benzbromarone. 2.Inhibit uric acid production drugs: The mechanism of these drugs is that allopurinol reduces uric acid production by inhibiting xanthine oxidase, which is suitable for those who have excessive uric acid production or are not suitable for using uric acid excreting drugs. The dose should be reduced in patients with renal insufficiency and prohibited in patients with G5 stage of renal insufficiency (uremic phase). 3.Alkaline drugs: sodium bicarbonate can alkalize the urine, so that uric acid is not easy to gather in the urine to form crystals. 4.New uric acid-lowering drugs: ①Uric acid oxidase: decompose uric acid into soluble products for excretion; ②Selective uric acid reabsorption inhibitors. In addition to drug treatment, patients with hyperuricemia should also pay attention to control the total calories of diet; limit the intake of alcohol and high purine food; drink a lot of water to increase the excretion of uric acid; use drugs that inhibit uric acid excretion such as thiazide diuretics carefully; avoid triggering factors and actively treat related diseases. Therefore, there are several drugs to lower uric acid, but the specific drugs should be selected according to the cause and condition of the patient, and in addition to drug treatment should also pay attention to its general treatment, so as to achieve better treatment results.