Immunohistochemical tests for gastrointestinal mesenchymal tumors include CD117 and DOG1.
CD117, also known as c-Kit, is a cytokine receptor that is expressed on the cell surface of hematopoietic stem cells and other cell types.DOG1 protein is selectively expressed in gastrointestinal mesenchymal tumors, and compared with KIT/CD117, DOG1 is a much more sensitive and specific GIST markers.
If both CD117 and DOG1 are diffusely positive, a diagnosis of gastrointestinal mesenchymal tumor is made. If either is positive, a diagnosis of gastrointestinal mesenchymal tumor can be made if the histology is consistent with mesenchymal tumor and if other tumors can be excluded. If both are negative, the histology needs to be consistent with mesenchymal tumors and other tumors can be ruled out, and genetic mutations need to be tested to help diagnose gastrointestinal mesenchymal tumors.
Patients with gastrointestinal mesenchymal tumors should go to the hospital for surgical treatment in time to avoid delays and adverse consequences.