Soreness and weakness of hands and feet may be caused by mental and nutritional diseases, diabetes, chronic nephritis and other reasons. 1. Mental and nutritional disease causes: if the patient is malnourished, depressed, etc., it is possible to have the feeling of weak and tired hands and feet. Patients can improve by supplementing nutrition, regulating the spirit and so on. 2. Diabetes mellitus: Diabetes mellitus is the most common symptom leading to aching and weakness of hands and feet. Due to abnormal glucose metabolism, reduction of high-energy phosphoric acid bonding, negative nitrogen balance, loss of water and electrolyte imbalance, etc., the patient is prone to symptoms such as fatigue, weakness, thirst, weight loss and excessive drinking. It can be improved by adjusting blood sugar and treating complications. 3. Chronic nephritis: chronic nephritis, renal tubular reabsorption function is weakened, protein leakage increased, blood potassium decreased patients also often feel weak and tired hands and feet, and chronic nephritis patients long-term consumption of low-salt or no-salt diet, it is very easy to lack of potassium, which can cause so there will be weak and fatigue symptoms, through the treatment of chronic nephritis itself and to correct the balance of water and electrolyte sodium, potassium can be improved. There are many other reasons for patients to have weak and tired hands and feet, it is recommended to go to the regular hospital in time for examination, and combined with the cause of the targeted treatment.