Knee creaking when squatting and getting up may be physiological popping, and may also be caused by meniscus injury, osteoarthritis, synovial crease syndrome and other factors. 1. Physiological popping: a long time without exercise or squatting for too long, when you get up, due to the cartilage and cartilage friction between each other, there will be a physiological popping, there are no other clinical symptoms, is a physiological phenomenon. 2. Meniscus injury: the meniscus suffered acute injury, after tearing stuck between the joints, in the flexion and extension of the knee joint, will cause the knee joint ringing, may also be accompanied by pain, limited activities and other symptoms. 3. Osteoarthritis: when the age increases, the cartilage may gradually degenerate, and aseptic inflammation will occur, in the process of knee flexion and extension, it will cause ringing, which may be accompanied by pain, and when it is serious, it will lead to localized swelling. 4. Synovial crease syndrome: may be traumatic, knee overuse and other factors, will lead to localized swelling of the knee joint and a small amount of fluid, in the activities of the knee joint will appear mild popping sound. Squatting up when the knee creaking, and exclude physiological factors, but also accompanied by pain and other symptoms, should be vigilant for pathological factors, it is recommended to consult a doctor for examination and treatment.