Diabetic patients with lower limb weakness and difficulty walking need to pay attention to the following conditions: 1. Poor glycemic control. Poorly controlled blood glucose can lead to metabolic abnormalities, causing negative nitrogen balance, which can lead to weakness, fatigue and other conditions. If the patient has weakness of the lower limbs, numbness of the limbs, and the condition of one limb, it is recommended to improve the cranio-cerebral imaging to exclude the possibility of acute cerebrovascular lesions. 3. The screening of peripheral neuropathy and vasculopathy, because the lower limb weakness can occur in diabetic patients with combined lower limb vascular stenosis or diabetic peripheral neuropathy, which can be improved by actively giving nerve-nourishing and circulation-improving drugs. 4, pay attention to whether the patient has electrolyte disorders, such as whether the combination of hypokalemia, if hypokalemia patients also have weakness of the lower limbs. 5, to pay attention to the patient’s nutritional status, such as the presence of anemia, if there is anemia, the patient also has the symptoms of weakness with panic. Therefore, for diabetic patients with lower limb weakness, attention should be paid to actively screen for the above-mentioned causes and treat them symptomatically.