If diabetic patients have leg pain, there are two causes caused by: 1. Diabetic peripheral neuropathy, mainly refers to the diabetic bilateral lower limb sensory nerve lesions, patients will appear numbness, pain, abnormal sensation and other symptoms of the bilateral lower limbs. Mainly take oral nerve-nourishing drugs, like epalrestat, methylcobalamin, etc., these drugs in the treatment of peripheral neuropathy has a relatively good efficacy affected. If the pain is more obvious, you can also take oral non-steroidal analgesic drugs to relieve pain, the effect of oral pain relief at night is better. 2, patients combined with arterial vascular lesions of the lower limbs, mainly seen in the lower limb arterial occlusion, will cause ischemic pain of the lower limbs. Internal medicine is oral beraprost sodium drugs, these drugs have the effect of dilating arteries and improving blood supply, which can relieve the pain caused by lower limb ischemia to a certain extent. If oral medication is not effective, the patient should consider going to vascular surgery to take an interventional approach to open the occluded blood vessels and resolve the pain caused by ischemia.