In this season of “blowing not cold willow wind” is an allergy-prone season, I have heard of allergic rhinitis, allergic cough, allergic dermatitis, but have I heard of semen allergy? Condom allergy? These allergies can be a bit special ah, for both sexes life is extremely embarrassing ah! Here we talk about these special allergies. I, semen allergy had heard of a case in the gynecology department, Xiao Liu, 22 years old, about 40 minutes after the first sexual intercourse newlywed skin and vaginal opening itchy, about 3 hours after the symptoms gradually alleviated. The second time she had the same symptoms and came to the clinic with unbearable itching at the vaginal opening. After examination, she was found to have a red rash on the skin and vulva, and was considered to have semen allergy. 1. Definition Semen allergy refers to the allergic reaction caused by semen entering the body of a woman with allergic constitution, causing microvascular dilatation and increased permeability of local (vaginal) or general skin and mucous membrane, swelling of eyelids, lips, etc., and causing infertility in severe cases. Semen is a special substance with complex composition, including proteins and more than 30 kinds of antigens in addition to sperm, but it usually does not cause an immune response after entering the female reproductive tract because seminal plasma immunoinhibition material (SPIA) is contained in seminal plasma. The pregnancy-associated protein A, also known as male inhibitory material (MIM), inhibits the body’s immune response to sperm and protects the fertilized egg from rejection, making it difficult to maintain normal reproductive physiology. When the MIM activity of the female partner is reduced, the antigenicity of semen is enhanced, and the female happens to be allergic, the semen will cause an allergic reaction when it enters the female body. 3. Prevention (1) Use condoms to prevent semen from entering the woman’s body; (2) Half an hour before intercourse, the woman can prophylactically take oral anti-allergy medication, such as paracetamol, reserpine, etc.; (3) During intercourse, apply a little skin relaxation or dexamethasone ointment to the woman’s vulva and vagina to prevent or reduce local allergic reactions; (4) Immediately after intercourse, the woman urinates to let semen flow out of the vagina, and (4) Immediately after intercourse, the woman should urinate, let the semen flow out from the vagina, and wash the vulva and vaginal opening with warm water; (5) Immediately after an allergic reaction to semen, take oral anti-allergy medication. (5) After an allergic reaction to semen occurs, take oral anti-allergy medication immediately. Apply dermatologic or dexamethasone ointment to treat local allergic rash. For severe allergy, seek prompt medical treatment. If women are considering childbirth, it is not recommended to use anti-allergy medication and topical hormone creams as a preventive method, but to actively seek medical desensitization treatment and then prepare for pregnancy and childbirth. Second, condom allergy Although the phenomenon of condom allergy is very rare, but it does exist. As one of the conventional contraceptive methods, condoms are generally made of natural latex, safe, effective, no side effects. However, some allergic people may also be allergic to them. 1. Definition Generally speaking, men show redness, swelling, itching and tingling in the pubic area, and in serious cases, even breakage and erosion; women have itching, burning sensation, vaginal congestion, and increased leucorrhea in the pubic area. When the above symptoms appear after having sex with condoms, the possibility of condom allergy should be considered. 2. Etiology The current production of latex condoms are using methyl silicone oil for isolation and lubrication, which has greatly reduced the chances of causing allergy to users. However, condoms are chemical products after all, and some people, especially those with allergies, may still be allergic to latex or lubricants. (1) stop using condoms and use other contraceptive measures or choose non-latex condoms; (2) stop having sex during treatment and within 2 weeks after recovery; (3) don’t scratch locally and don’t wash with hot water or soap to prevent aggravation of the lesion; (4) apply some anti-allergy ointment to the allergic area to improve allergy symptoms and prevent infection; (5) take anti-allergy drugs (5) Take anti-allergy drugs, such as paracetamol, cyproheptadine, reserpine, etc. Condom-induced allergic reactions, generally after 5-7 days of treatment, can return to normal.