Small bumps bubble generally known as blisters and pimples, blisters or pimples on the palm of the hand may be caused by hand, foot and mouth disease, chickenpox or ringworm and other diseases. 1. Hand, foot and mouth disease: Coxsackievirus A16 virus, enterovirus 71 and other coxsackieviruses can cause hand, foot and mouth disease, which can be transmitted by droplet transmission or fecal-oral and other ways. There are often prodromal symptoms such as low-grade fever, headache, etc., followed by skin lesions and papules on the hands, feet and mouth, forming blisters with thin walls. 2. Chickenpox: It is caused by varicella zoster virus infection, the primary infection forms chickenpox, transmitted through the patient’s nasopharyngeal secretion droplets, direct contact with the blister fluid, etc. It can be found on the trunk, limbs, palms and plants, etc. First, the macular papules appear, and then blisters are formed gradually. 3. ringworm: mainly by the red trichophyton, ringworm fungus and other dermatophytes invasion of the palm of the hand, between the fingers and other skin caused by fungal infections, mainly through contact infections, the hands can have papules and blisters, blister wall is thicker, it is not easy to break. Blisters and pimples on the palms of the hands may also have other causes, it is recommended to promptly go to the hospital, give targeted treatment after diagnosis.