There is no such thing as “the best time to take Metformin Extended-Release Tablets before bedtime”, if you only take it once a day, it is recommended to take it with dinner. Metformin extended-release tablets belong to the biguanide class of hypoglycemic drugs, can inhibit the output of hepatic glucose, increase the utilization of glucose in peripheral tissues, improve insulin sensitivity, reduce blood glucose. It is suitable for the treatment of patients with type 2 diabetes whose blood sugar cannot be well controlled by diet control and exercise therapy alone. There may be adverse reactions such as nausea, vomiting, abdominal pain after taking the drug. Allergic to the drug, liver and kidney insufficiency, heart failure, acute metabolic acidosis and other patients are prohibited; the drug is recommended to be taken with meals, if the drug is taken only once a day, then it is recommended to be taken with dinner, so there is no such thing as “the best time to take Metformin Extended-Release Tablets before bedtime”. Patients who need to use Metformin Extended-Release Tablets should take it under the guidance of a doctor.