The advantages of tenofovir: 1, the strongest antiviral effect; 2, the lowest rate of drug resistance, zero resistance rate; 3, the control of hepatitis B-related liver inflammation is the most rapid and most complete; 4, reverse hepatitis B-related liver fibrosis and even cirrhosis, the most accurate efficacy; 5, may be able to minimize the incidence of liver cancer; 6, tenofovir does not affect fertility and breastfeeding, is the major authoritative hepatitis B guidelines recommend hepatitis B pregnant women It is the drug of choice for pregnant women with hepatitis B. Disadvantages of tenofovir: 1, adverse reactions than entecavir will be slightly more, such as a small number of patients creatine kinase rise, transaminases long-term high, rash, increased stool and some other discomfort, some individual patients can not tolerate and change the drug; 2, there is a very slight risk of kidney damage, not suitable for patients with chronic kidney disease; 3, the current price is more expensive, is the five oral anti-hepatitis B virus drugs It is the most expensive of the five oral anti-hepatitis B virus drugs.