Gallbladder polyp lesions are not uncommon clinically, and surgery is the radical cure, but not all gallbladder polyps require surgical treatment. Because of the different types of lesions, sizes and disease regression, the indications for surgery are not consistent. Timing of surgery: Gallbladder polyp-like lesions are sometimes difficult to characterize preoperatively. According to the high risk factors for malignant transformation of gallbladder polyp-like lesions, we propose the following surgical indications: (1) Single lesion, larger than 10 mm, with a thick tip, especially if located in the neck of the gallbladder and older than 50 years of age. (2) Multiple lesions with gallbladder stones, symptomatic, and age >50 years. (3) Single lesion, less than 10 mm, asymptomatic, age less than 50 years, observation and follow-up are allowed; lesions that increase in size or change in morphology should be treated surgically. (4) Doppler ultrasound examination of the lesion with abundant blood supply suggests a malignant neoplasm. (5) CEA (tumor marker), the measured value is significantly increased and other gastrointestinal tumors are excluded. (6) Gallbladder polyp-like lesions with significant symptoms and recurrent recurrence. (7) Asymptomatic patients with diameter less than 5 mm should be followed up at intervals of 3 to 5 months. Once the lesion is enlarged or symptomatic, surgery should be performed.