Most mouth ulcers do not require the use of cephalosporin antibiotics, only a small percentage of mouth ulcers can be considered for the use of cephalosporin antibiotics. Mouth ulcers are very common oral diseases, leading to mouth ulcers for a variety of reasons, most and personal constitution and eating habits have a certain relationship, a small number of mouth ulcers may be secondary to the underlying disease. After the appearance of mouth ulcers, the main manifestation of localized pain, and may even affect the patient’s diet, sleep and so on. For the treatment of mouth ulcers, most of the local symptomatic treatment should be carried out, pay attention to maintain oral hygiene, rinse the mouth in time after meals, and at the same time can be used to clear the heat and detoxification, improve the local inflammation of the drugs for treatment, such as tin powder, ice boron powder and so on, which can alleviate the symptoms of pain. If the mouth ulcers appear secondary infection or consider primary bacterial infection, when there is obvious inflammatory reaction, you can use cephalosporin antibiotics for anti-infection treatment. Antibiotics should strictly grasp the indications for treatment, do not casually use antibiotics after the emergence of mouth ulcers, which can easily lead to the abuse of antibiotics.