The specific treatment of softening foci needs to be combined with the actual situation of the site and size of the softening foci, and the treatment plan is slightly different for different etiologies, the common etiologies are cerebral hemorrhage, cerebral infarction, encephalitis and traumatic brain injury, etc. Specific details are as follows: First, let’s clarify whether the softening foci are caused by hemorrhage or ischemia, further clarify the cause of the patient, and perform cranial MRI can assist in the diagnosis, and the treatment is based on improving circulation and nutrition of brain cells. If the patient has physical activity disorders, rehabilitation exercises should be actively given to help recovery. Second, due to encephalitis, such as septic meningitis, viral meningitis, symptoms can gradually improve after active treatment of the original disease, while giving nutritional brain cells, rehabilitation exercises, etc. can help recovery. Third, note that the softening foci are mostly due to local ischemia caused by various reasons, so the treatment should be combined with the actual situation of the patient, and give drugs to activate blood circulation, improve circulation and anti-platelet aggregation, pay attention to the review of blood routine and coagulation index, pay attention to avoid strain, pay attention to rest, quit smoking and alcohol, etc.