Foci of tenderness are descriptive imaging terms that can be observed on cranial CT or cranial MRI. It can be secondary to any kind of neurological disease, mainly substantial brain cell damage, and can be followed by softening foci, which are more common in various types of cerebrovascular disease, encephalitis, and after brain tumor surgery. For example, softening foci can appear after cerebral infarction and cerebral hemorrhage. When cerebral infarction and cerebral hemorrhage cause destruction of brain cells, the liquefied necrosis will be gradually absorbed by the surrounding tissues, forming a cavity in the original place, after which glial cells will proliferate and gradually fill the cavity to form scar tissue, which will be shown as softening foci on CT or MRI, suggesting that it is a non-acute old lesion. However, if the softening foci persist for a long time, there is a possibility of secondary epilepsy.