Softening foci generally have no effect on life expectancy. Somatic signs and symptoms, such as hemiparesis, hemianopia, and hemianesthesia, may occur if the soft focus is large. Some patients may experience seizures. If frequent grand mal seizures may cause impaired brain function, the patient may experience memory loss, inattention and disorganized thinking, and may also cause intellectual disability, which may have an impact on the patient’s life expectancy. Most of the softening foci are due to patients suffering from cerebral infarction and cerebral hemorrhage, which are left as a kind of stroke capsule after aggressive and correct treatment, and usually do not require special treatment. If the patient has signs and symptoms, symptomatic treatment is mainly given. In patients with seizures with more than 2 seizures, antiepileptic drugs can be given, commonly used drugs are sodium valproate and carbamazepine. If the physical symptoms and signs are severe, rehabilitation and physiotherapy can be given to prevent muscle atrophy and muscle contracture, and at the same time to improve brain metabolism treatment, the commonly used drugs are olanzapine, piracetam and cytarabine.