There are many reasons for the relapse of depression, mainly the following: 1. It is possible that the depressed person has encountered frustration, stress and other psychosocial factors, such as marital discord, more family conflicts, heavy economic burden, interpersonal tension and so on. These reasons are likely to make people depressed and irritable, and even make depression relapse. 2, it may also be caused by personality factors, some people are introverted, sensitive and suspicious, even to some small things will love to get into a corner, repeatedly thinking, repeatedly put themselves in a painful situation, this time it is easy to lead to a relapse of depression. 3, it may also be caused by premature discontinuation of medication, because depression is very If the condition is not yet stable, or stable after not maintaining and consolidating treatment, premature discontinuation of medication will easily lead to relapse of depression, the above reasons are more common.