The leg pain of a 64-year-old woman for 3 years may be caused by calcium deficiency or overwork, osteoarthritis of the knee joint, lumbar disc herniation, etc. It can be relieved by proper rest, oral non-steroidal drugs, artificial disc replacement surgery, and other methods. 1. Calcium deficiency or overwork: Calcium deficiency or overwork will stimulate re-inflammation of the joints and surrounding tissues and lead to leg pain, which can be relieved by proper rest and eating high calcium foods, such as milk, soybean products, vegetables and fruits, etc., and can also be relieved by using medicines such as Calcium Carbonate and Vitamin D3 tablets under the guidance of a doctor. 2. Osteoarthritis of the knee: Osteoarthritis of the knee can lead to obvious knee pain, joint swelling, squatting activities are limited, triggering leg pain. It can be relieved by taking oral non-steroidal drugs such as celecoxib capsules or diclofenac sodium enteric-coated tablets. 3. Lumbar disc herniation: due to the herniated nucleus pulposus compressing the sciatic nerve causing the whole leg pain, if mild can be relieved by lying in bed for three weeks, oral anti-inflammatory painkillers such as methylcobalamin tablets, losoprofen sodium tablets, etc., if serious, you need to perform artificial disc replacement surgery or minimally invasive intervertebral foramenoscopy surgery to treat the problem. If there is a 64-year-old woman leg pain for three years, it is recommended to seek medical attention in a timely manner, to clarify the cause of the disease to take the appropriate treatment program, the drugs need to be taken under the guidance of a doctor, so as not to cause adverse consequences.