Urethral irritation should be based on the pathogen to choose to take drugs, including antibiotics, anti-tuberculosis drugs and so on. 1. Antibiotic treatment: acute urinary tract infections often have signs of urinary tract irritation manifestations, should be based on the location of urinary tract infection, the type of causative organisms to choose sensitive, side-effects of antibiotic treatment. (1) Acute cystitis: can take compound sulfamethoxazole 3 days treatment, can also be used amoxicillin, cephalosporins or quinolone antibiotic treatment, the course of treatment is generally 3 ~ 7 days. At the same time, attention should be paid to rest, drink more water and urinate regularly. (2) Acute pyelonephritis: oral levofloxacin and other quinolone antibiotic treatment, the course of treatment is 10~14 days; severe infection or fever, fatigue, severe should be hospitalized, intravenous drug. 2. Anti-tuberculosis treatment: urinary tract tuberculosis such as renal tuberculosis will cause obvious urinary tract irritation manifestations such as urinary urgency, urinary frequency, urinary pain, etc. Anti-tuberculosis drugs such as isoniazid, rifampicin, ethambutol, etc. should be given to treat the patients, following the principles of early, regular going, proper dosage, whole course, and combined treatment. It is recommended to actively seek medical treatment and follow the doctor’s instructions.