Patients allergic to cephalosporins, clinically available macrolide antibiotics, quinolone antibiotics, lincomycin antibiotics and other alternative treatment: 1, macrolide antibiotics: mainly including erythromycin, clarithromycin, azithromycin, roxithromycin, etc., mainly through the inhibition of bacterial protein synthesis to achieve a certain degree of inhibition of the bacterial effect, the high concentration can be bactericidal, and it is mainly on the majority of Gram Positive bacteria, anaerobic cocci and some gram-negative bacteria including Neisseria, Haemophilus and Corynebacterium diphtheriae have strong antibacterial activity, which can be used as alternative treatment when patients are allergic to cephalosporin; 2. Quinolone antibiotics: mainly including Norfloxacin, Ciprofloxacin, Oxyfloxacin, Levofloxacin, etc., which has wide antimicrobial spectrum, and has stronger inhibitory effect on gram-negative bacteria than gram-positive ones, and is an efficient and safe class of drugs to treat a variety of infectious diseases. Lincomycin antibiotics: mainly including lincomycin, clindamycin, etc., mainly on all kinds of anaerobic bacteria have antibacterial effect, on aerobic gram-positive bacteria have significant activity, on part of aerobic gram-negative cocci, Mycoplasma hominis and Chlamydia trachomatis also have a certain inhibitory effect, can be a substitute for the cephalosporin for antibacterial treatment. Serious infections choose ticlopidine, fusidic acid, linezolid and other drugs under the mirror treatment, should be selected by the specialist according to the condition of the patient in the use of antibiotics for treatment, should pay attention to all kinds of contraindications to medication, especially the elderly patients, patients with chronic diseases, etc., during the use of medication, try to avoid drinking alcohol, eating spicy and stimulating food, if there is diarrhea, nausea, vomiting and other serious adverse reactions, should be promptly to the hospital, follow the doctor’s instructions to adjust the medication. If serious adverse reactions such as diarrhea, nausea, vomiting occur, the patient should go to the hospital in time and adjust the medication according to the doctor’s advice.