Periapical pain may be caused by physiological factors such as exertion, shoulder trauma, frozen shoulder, cervical spondylosis and so on. 1. Physiological factors: Due to over-exertion of the shoulder joint, such as carrying goods, the metabolic products of the local muscles can not be discharged in time, and peri-shoulder pain occurs. 2. Shoulder trauma: due to trauma and other direct or indirect violence on the shoulder, causing shoulder fracture, joint injury or surrounding soft tissue injury, peri-shoulder pain can occur. 3. Frozen shoulder: Aseptic inflammation around the shoulder joint caused by cold, long-term shoulder labor and other factors may cause pain around the shoulder joint and restriction of activities. 4. Cervical spondylosis: Due to degeneration of cervical vertebrae, cervical intervertebral disc herniation is caused, which oppresses the nerve root innervating the upper limb, and may cause pain, numbness, and activity limitation around the shoulder. There may be other causes of pain in the peri-shoulder area, so it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy.