Multiple bone destruction needs to be considered in the context of infections, malignant tumors, and hematologic disorders. Multiple bone destruction is a pathologic condition, and most of the symptoms are secondary to other diseases. 1. Infectious factors: Osteomyelitis can be caused by bacterial, viral, tuberculosis and other infections, which can lead to the formation of bone cavities and dead bones, destroying normal bone quality. 2. Malignant tumors: malignant tumors develop infiltration and break through the bone, which can cause bone destruction and osteoporosis at the metastatic site. 3. Hematologic diseases: some patients with lymphoblastoma and lymphoma will also have bone destruction, and there will also be hematologic symptoms such as decreased blood cells. When multiple bone destruction occurs, it is recommended to seek medical examination in time to further find out the cause of the disease, and actively treat the disease under the guidance of doctors to avoid aggravation and deterioration of the condition.